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Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition. Separase is inhibited prior to metaphase by the tightly bound securin protein, which contains a pseudosubstrate motif that blocks the separase active site....
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858450/ https://ncbi.nlm.nih.gov/pubmed/31729382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13209-y |
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