Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I

Proteolytic activity of separase is required for chiasma resolution during meiosis I in mouse oocytes. Rec8, the meiosis-specific α-kleisin subunit of cohesin, is a key target of separase in yeast. Is the equivalent protein also a target in mammals? We show here that separase cleaves mouse Rec8 at t...

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Autors principals: Kudo, Nobuaki R., Anger, Martin, Peters, Antoine H. F. M., Stemmann, Olaf, Theussl, Hans-Christian, Helmhart, Wolfgang, Kudo, Hiromi, Heyting, Christa, Nasmyth, Kim
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2009
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909317/
https://ncbi.nlm.nih.gov/pubmed/19625504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.035287
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