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Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
Proteolytic activity of separase is required for chiasma resolution during meiosis I in mouse oocytes. Rec8, the meiosis-specific α-kleisin subunit of cohesin, is a key target of separase in yeast. Is the equivalent protein also a target in mammals? We show here that separase cleaves mouse Rec8 at t...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Company of Biologists
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909317/ https://ncbi.nlm.nih.gov/pubmed/19625504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.035287 |
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