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Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase
Chromosome segregation is triggered by separase, an enzyme that cleaves cohesin, the protein complex that holds sister chromatids together. Separase activation requires the destruction of its inhibitor, securin, which occurs only upon the correct attachment of chromosomes to the spindle. However, ot...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Cold Spring Harbor Laboratory Press
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2661608/ https://ncbi.nlm.nih.gov/pubmed/19299562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.507509 |
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