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Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation
In anaphase, sister chromatids separate abruptly and are then segregated by the mitotic spindle. The protease separase triggers sister separation by cleaving the Scc1/Mcd1 subunit of the cohesin ring that holds sisters together. Polo-kinase phosphorylation of Scc1 promotes its cleavage, but the unde...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413326/ https://ncbi.nlm.nih.gov/pubmed/22814605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.06.007 |
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