Loading...
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition. Separase is inhibited prior to metaphase by the tightly bound securin protein, which contains a pseudosubstrate motif that blocks the separase active site....
Saved in:
| Published in: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2019
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858450/ https://ncbi.nlm.nih.gov/pubmed/31729382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13209-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|