Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site

Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition. Separase is inhibited prior to metaphase by the tightly bound securin protein, which contains a pseudosubstrate motif that blocks the separase active site....

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Bibliographic Details
Published in:Nat Commun
Main Authors: Rosen, Laura E., Klebba, Joseph E., Asfaha, Jonathan B., Ghent, Chloe M., Campbell, Melody G., Cheng, Yifan, Morgan, David O.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858450/
https://ncbi.nlm.nih.gov/pubmed/31729382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13209-y
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