Human MYD88(L265P) is insufficient by itself to drive neoplastic transformation in mature mouse B cells

MYD88(L265P) is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 pathway has an adverse impact on LPL/WM and DLBCL c...

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Udgivet i:Blood Adv
Main Authors: Sewastianik, Tomasz, Guerrera, Maria Luisa, Adler, Keith, Dennis, Peter S., Wright, Kyle, Shanmugam, Vignesh, Huang, Ying, Tanton, Helen, Jiang, Meng, Kofides, Amanda, Demos, Maria G., Dalgarno, Audrey, Patel, Neil A., Nag, Anwesha, Pinkus, Geraldine S., Yang, Guang, Hunter, Zachary R., Jarolim, Petr, Munshi, Nikhil C., Treon, Steven P., Carrasco, Ruben D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855113/
https://ncbi.nlm.nih.gov/pubmed/31698464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000588
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