SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas

Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to primary drug resistance. B-cell receptor (BCR) signali...

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Publicado no:Blood Cancer J
Main Authors: Munshi, Manit, Liu, Xia, Chen, Jiaji G., Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Guerrera, Maria Luisa, Jimenez, Cristina, Chan, Gloria G., Hunter, Zachary R., Palomba, M. Lia, Argyropoulos, Kimon V., Meid, Kirsten, Keezer, Andrew, Gustine, Joshua, Dubeau, Toni, Castillo, Jorge J., Patterson, Christopher J., Wang, Jinhua, Buhrlage, Sara J., Gray, Nathanael S., Treon, Steven P., Yang, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994488/
https://ncbi.nlm.nih.gov/pubmed/32005797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-020-0277-6
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