Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas

Hematopoietic cell kinase (HCK) is an SRC family member that is aberrantly upregulated in B-cell neoplasms dependent on MYD88-activating mutations and supports their growth and survival. We showed herein that activation of Toll-like receptor (TLR) signaling in MYD88 wild-type B cells also triggered...

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Vydáno v:Blood Adv
Hlavní autoři: Liu, Xia, Chen, Jiaji G., Munshi, Manit, Hunter, Zachary R., Xu, Lian, Kofides, Amanda, Tsakmaklis, Nickolas, Demos, Maria G., Guerrera, Maria Luisa, Chan, Gloria G., Jimenez, Cristina, Patterson, Christopher J., Meid, Kirsten, Keezer, Andrew, Castillo, Jorge J., Treon, Steven P., Yang, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960458/
https://ncbi.nlm.nih.gov/pubmed/31935288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000947
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