Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia

Activating MYD88 mutations are present in 95% of Waldenström macroglobulinemia (WM) patients, and trigger NF-κB through BTK and IRAK. The BTK inhibitor ibrutinib is active in MYD88-mutated (MYD88(MUT)) WM patients, but shows lower activity in MYD88 wild-type (MYD88(WT)) disease. MYD88(WT) patients a...

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Foilsithe in:Blood Adv
Main Authors: Hunter, Zachary R., Xu, Lian, Tsakmaklis, Nickolas, Demos, Maria G., Kofides, Amanda, Jimenez, Cristina, Chan, Gloria G., Chen, Jiaji, Liu, Xia, Munshi, Manit, Gustine, Joshua, Meid, Kirsten, Patterson, Christopher J., Yang, Guang, Dubeau, Toni, Samur, Mehmet K., Castillo, Jorge J., Anderson, Kenneth C., Munshi, Nikhil C., Treon, Steven P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2018
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234368/
https://ncbi.nlm.nih.gov/pubmed/30401751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018022962
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