Human MYD88(L265P) is insufficient by itself to drive neoplastic transformation in mature mouse B cells

MYD88(L265P) is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 pathway has an adverse impact on LPL/WM and DLBCL c...

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Publicat a:Blood Adv
Autors principals: Sewastianik, Tomasz, Guerrera, Maria Luisa, Adler, Keith, Dennis, Peter S., Wright, Kyle, Shanmugam, Vignesh, Huang, Ying, Tanton, Helen, Jiang, Meng, Kofides, Amanda, Demos, Maria G., Dalgarno, Audrey, Patel, Neil A., Nag, Anwesha, Pinkus, Geraldine S., Yang, Guang, Hunter, Zachary R., Jarolim, Petr, Munshi, Nikhil C., Treon, Steven P., Carrasco, Ruben D.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855113/
https://ncbi.nlm.nih.gov/pubmed/31698464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000588
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