Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

BACKGROUND: Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ induces stress-responsive cellular programs known to prom...

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Publicado en:Mol Med
Autores principales: Harder, Bryan G., Peng, Sen, Sereduk, Christopher P., Sodoma, Andrej M., Kitange, Gaspar J., Loftus, Joseph C., Sarkaria, Jann N., Tran, Nhan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854621/
https://ncbi.nlm.nih.gov/pubmed/31726966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0116-z
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