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Modeling conformational flexibility of kinases in inactive states
Kinase structures in the inactive “DFG‐out” state provide a wealth of druggable binding site variants. The conformational plasticity of this state can be mainly described by different conformations of binding site‐forming elements such as DFG motif, A‐loop, P‐loop, and αC‐helix. Compared to DFG‐in s...
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| Veröffentlicht in: | Proteins |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley & Sons, Inc.
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6852311/ https://ncbi.nlm.nih.gov/pubmed/31168936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25756 |
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