A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180° with respect to the active conformation, underlies the specifi...

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Bibliografski detalji
Glavni autori: Levinson, Nicholas M, Kuchment, Olga, Shen, Kui, Young, Matthew A, Koldobskiy, Michael, Karplus, Martin, Cole, Philip A, Kuriyan, John
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2006
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450098/
https://ncbi.nlm.nih.gov/pubmed/16640460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040144
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