A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180° with respect to the active conformation, underlies the specifi...

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Détails bibliographiques
Auteurs principaux: Levinson, Nicholas M, Kuchment, Olga, Shen, Kui, Young, Matthew A, Koldobskiy, Michael, Karplus, Martin, Cole, Philip A, Kuriyan, John
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450098/
https://ncbi.nlm.nih.gov/pubmed/16640460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040144
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