The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain

The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic activity, while phosphorylation of a C-termin...

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Bibliografiske detaljer
Main Authors: Levinson, Nicholas M., Visperas, Patrick R., Kuriyan, John
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766628/
https://ncbi.nlm.nih.gov/pubmed/19888460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007683
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