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Sequence Determinants of a Specific Inactive Protein Kinase Conformation
Only a small percentage of protein kinases have been shown to adopt a distinct inactive ATP-binding site conformation, called the Asp-Phe-Gly-out (DFG-out) conformation. Given the high degree of homology within this enzyme family, we sought to understand the basis of this disparity on a sequence lev...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742363/ https://ncbi.nlm.nih.gov/pubmed/23790491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.05.005 |
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