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Affinity Reagents that Target a Specific Inactive Form of Protein Kinases
A number of small-molecule inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is characterized by an almost 180° rotation...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871157/ https://ncbi.nlm.nih.gov/pubmed/20189109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.01.008 |
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