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MCC950 closes the active conformation of NLRP3 to an inactive state
NLRP3 is an innate immune sensor contributing to the development of different diseases including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer’s disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibitor with potential clinical utility. However, the mech...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116292/ https://ncbi.nlm.nih.gov/pubmed/31086329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0278-6 |
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