NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible fo...

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Publicado en:Nat Commun
Autores principales: Hafner-Bratkovič, Iva, Sušjan, Petra, Lainšček, Duško, Tapia-Abellán, Ana, Cerović, Kosta, Kadunc, Lucija, Angosto-Bazarra, Diego, Pelegrin, Pablo, Jerala, Roman
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281599/
https://ncbi.nlm.nih.gov/pubmed/30518920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07573-4
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