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NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible fo...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6281599/ https://ncbi.nlm.nih.gov/pubmed/30518920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07573-4 |
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