A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli

Monoclonal antibodies (mABs) are of great biopharmaceutical importance for the diagnosis and treatment of diseases. However, their production in mammalian expression hosts usually requires extensive production times and is expensive. Escherichia coli has become a new platform for production of funct...

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Vydáno v:Appl Microbiol Biotechnol
Hlavní autoři: Petrus, Marloes L. C., Kiefer, Lukas A., Puri, Pranav, Heemskerk, Evert, Seaman, Michael S., Barouch, Dan H., Arias, Sagrario, van Wezel, Gilles P., Havenga, Menzo
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2019
Témata:
Biotechnologically Relevant Enzymes and Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851033/
https://ncbi.nlm.nih.gov/pubmed/31641814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-10145-1
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