A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli

Monoclonal antibodies (mABs) are of great biopharmaceutical importance for the diagnosis and treatment of diseases. However, their production in mammalian expression hosts usually requires extensive production times and is expensive. Escherichia coli has become a new platform for production of funct...

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Bibliografske podrobnosti
izdano v:Appl Microbiol Biotechnol
Main Authors: Petrus, Marloes L. C., Kiefer, Lukas A., Puri, Pranav, Heemskerk, Evert, Seaman, Michael S., Barouch, Dan H., Arias, Sagrario, van Wezel, Gilles P., Havenga, Menzo
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Biotechnologically Relevant Enzymes and Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851033/
https://ncbi.nlm.nih.gov/pubmed/31641814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-10145-1
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