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Nonspecificity in a nonimmune human scFv repertoire

Efforts to develop effective antibody therapeutics are frequently hampered by issues such as aggregation and nonspecificity, often only detected in late stages of the development process. In this study, we used a high throughput cross-reactivity assay to select nonspecific clones from a naïve human...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Kelly, Ryan L., Zhao, Jessie, Le, Doris, Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627588/
https://ncbi.nlm.nih.gov/pubmed/28910564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1356528
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