A modular IgG-scFv bispecific antibody topology

Here we present a bispecific antibody (bsAb) format in which a disulfide-stabilized scFv is fused to the C-terminus of the light chain of an IgG to create an IgG-scFv bifunctional antibody. When expressed in mammalian cells and purified by one-step protein A chromatography, the bsAb retains parental...

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Bibliographic Details
Main Authors: Orcutt, Kelly Davis, Ackerman, Margaret E., Cieslewicz, Maryelise, Quiroz, Emmanuel, Slusarczyk, Adrian L., Frangioni, John V., Wittrup, K. Dane
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841541/
https://ncbi.nlm.nih.gov/pubmed/20019028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp077
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