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Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T-cell bispecific antibodies
T cell bispecific antibodies (BsAb) couple cytotoxic T lymphocytes to tumor cells, inducing their destruction. Although there are over 60 classes of BsAb in development, the relative importance of parameters such as interdomain spacing or spatial configuration are largely unknown. Here, we dissected...
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| Publicado no: | Sci Transl Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7437947/ https://ncbi.nlm.nih.gov/pubmed/32161106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax1315 |
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