Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors

Engineering potent bispecific antibodies from single-chain variable fragments (scFv) remains difficult due to the inherent instability and insufficient binding of scFv's compared to their parental immunoglobulin format. Previously, we described a scFv-based bispecific antibody (scBA) against di...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Cheng, Ming, Santich, Brian H., Xu, Hong, Ahmed, Mahiuddin, Huse, Morgan, Cheung, Nai-Kong V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938304/
https://ncbi.nlm.nih.gov/pubmed/27471647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1168557
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