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Reduction of nonspecificity motifs in synthetic antibody libraries
Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study we analyze the causes of one hurdle to clinical development, off-target reactivity or nonspecificity. We used a high-throughput nonspecificity assay to isolate panels of n...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5738262/ https://ncbi.nlm.nih.gov/pubmed/29183788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.11.008 |
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