Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium

Microtubule-associated protein tau associates with Src family tyrosine kinase Fyn and is tyrosine phosphorylated by Fyn. The presence of tyrosine phosphorylated tau in AD and the involvement of Fyn in AD has drawn attention to the tau-Fyn complex. In this study, a tau-Fyn double knockout (DKO) mouse...

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Bibliografske podrobnosti
izdano v:J Neurosci Res
Main Authors: Liu, Guanghao, Thangavel, Ramasamy, Rysted, Jacob, Kim, Yohan, Francis, Meghan B, Adams, Eric, Lin, Zhihong, Taugher, Rebecca J, Wemmie, John A, Usachev, Yuriy M, Lee, Gloria
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850396/
https://ncbi.nlm.nih.gov/pubmed/31452242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24517
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