The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations

Chronic myelomonocytic leukemia (CMML) is an aggressive myeloid neoplasm of older individuals characterized by persistent monocytosis. Somatic mutations in CMML are heterogeneous and only partially explain the variability in clinical outcomes. Recent data suggest that cardiovascular morbidity is inc...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Franzini, Anca, Pomicter, Anthony D., Yan, Dongqing, Khorashad, Jamshid S., Tantravahi, Srinivas K., Than, Hein, Ahmann, Jonathan M., O’Hare, Thomas, Deininger, Michael W.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849944/
https://ncbi.nlm.nih.gov/pubmed/31648319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000585
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