SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

We analyzed the mutational hotspot region of SRSF2 (Pro95) in 275 cases with chronic myelomonocytic leukemia (CMML). In addition, ASXL1, CBL, EZH2, JAK2V617F, KRAS, NRAS, RUNX1, and TET2 mutations were investigated in subcohorts. Mutations in SRSF2 (SRSF2mut) were detected in 47% (129 of 275) of all...

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Hauptverfasser: Meggendorfer, Manja, Roller, Andreas, Haferlach, Torsten, Eder, Christiane, Dicker, Frank, Grossmann, Vera, Kohlmann, Alexander, Alpermann, Tamara, Yoshida, Kenichi, Ogawa, Seishi, Koeffler, H. Phillip, Kern, Wolfgang, Haferlach, Claudia, Schnittger, Susanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580040/
https://ncbi.nlm.nih.gov/pubmed/22919025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-404863
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