JAK2(ex13InDel) drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

The V617F mutation in the JH2 domain of Janus kinase 2 (JAK2) is an oncogenic driver in several myeloproliferative neoplasms (MPNs), including essential thrombocythemia, myelofibrosis, and polycythemia vera (PV). Other mutations in JAK2 have been identified in MPNs, most notably exon 12 mutations in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Patel, Ami B., Franzini, Anca, Leroy, Emilie, Kim, Soo Jin, Pomicter, Anthony D., Genet, Lidvine, Xiao, Michael, Yan, Dongqing, Ahmann, Jonathan M., Agarwal, Archana M., Clair, Phillip, Addada, Juanah, Lambert, Jonathan, Salmon, Matthew, Gleich, Gerald J., Cross, Nicholas C. P., Constantinescu, Stefan N., O’Hare, Thomas, Prchal, Josef T., Deininger, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933291/
https://ncbi.nlm.nih.gov/pubmed/31697804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001385
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