JAK2(ex13InDel) drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

The V617F mutation in the JH2 domain of Janus kinase 2 (JAK2) is an oncogenic driver in several myeloproliferative neoplasms (MPNs), including essential thrombocythemia, myelofibrosis, and polycythemia vera (PV). Other mutations in JAK2 have been identified in MPNs, most notably exon 12 mutations in...

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Vydáno v:Blood
Hlavní autoři: Patel, Ami B., Franzini, Anca, Leroy, Emilie, Kim, Soo Jin, Pomicter, Anthony D., Genet, Lidvine, Xiao, Michael, Yan, Dongqing, Ahmann, Jonathan M., Agarwal, Archana M., Clair, Phillip, Addada, Juanah, Lambert, Jonathan, Salmon, Matthew, Gleich, Gerald J., Cross, Nicholas C. P., Constantinescu, Stefan N., O’Hare, Thomas, Prchal, Josef T., Deininger, Michael W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933291/
https://ncbi.nlm.nih.gov/pubmed/31697804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001385
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