GENE-15. TARGETING OF EPENDYMOMA AS INFORMED BY ONCOGENIC 3D GENOME ORGANIZATION

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. While enh...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Okonechnikov, Konstantin, Hübner, Jens-Martin, Chapman, Owen, Chakraborty, Abhijit, Bump, Rosalind, Chandran, Sahaana, Kraft, Katerina, Acuna Hidalgo, Rocio, Mundlos, Stefan, Coufal, Nicole, Levy, Michael, Crawford, John, Ay, Ferhat, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genetics and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847614/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.417
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