GENE-15. TARGETING OF EPENDYMOMA AS INFORMED BY ONCOGENIC 3D GENOME ORGANIZATION

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. While enh...

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書誌詳細
出版年:Neuro Oncol
主要な著者: Okonechnikov, Konstantin, Hübner, Jens-Martin, Chapman, Owen, Chakraborty, Abhijit, Bump, Rosalind, Chandran, Sahaana, Kraft, Katerina, Acuna Hidalgo, Rocio, Mundlos, Stefan, Coufal, Nicole, Levy, Michael, Crawford, John, Ay, Ferhat, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2019
主題:
Genetics and Epigenetics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847614/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.417
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