GENE-15. TARGETING OF EPENDYMOMA AS INFORMED BY ONCOGENIC 3D GENOME ORGANIZATION

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. While enh...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Okonechnikov, Konstantin, Hübner, Jens-Martin, Chapman, Owen, Chakraborty, Abhijit, Bump, Rosalind, Chandran, Sahaana, Kraft, Katerina, Acuna Hidalgo, Rocio, Mundlos, Stefan, Coufal, Nicole, Levy, Michael, Crawford, John, Ay, Ferhat, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Genetics and Epigenetics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847614/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.417
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