EPEN-04. ONCOGENIC 3D TUMOR GENOME ORGANIZATION IDENTIFIES NEW THERAPEUTIC TARGETS IN EPENDYMOMA

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. While enh...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Okonechnikov, Konstantin, Hübner, Jens-Martin, Chapman, Owen, Chakraborty, Abhijit, Pagadala, Meghana, Bump, Rosalind, Chandran, Sahaana, Kraft, Katerina, Hidalgo, Rocio Acuna, Mundlos, Stefan, Wechsler-Reya, Robert, Juarez, Edwin F, Coufal, Nicole, Levy, Michael, Crawford, John, Pajtler, Kristian, Reid, Derek, Schmitt, Anthony, Carter, Hannah, Ay, Ferhat, Dixon, Jesse, Mesirov, Jill, Pfister, Stefan M, Kool, Marcel, Chavez, Lukas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Ependymoma
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715851/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.145
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