GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. To associ...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Okonechnikov, Konstantin, Hübner, Jens-Martin, Kraft, Katerina, Hidalgo, Rocio Acuna, Bump, Rosalind, Chandran, Sahaana, Mundlos, Stefan, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genetics/Epigentics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477292/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.073
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