GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. To associ...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Okonechnikov, Konstantin, Hübner, Jens-Martin, Kraft, Katerina, Hidalgo, Rocio Acuna, Bump, Rosalind, Chandran, Sahaana, Mundlos, Stefan, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Genetics/Epigentics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477292/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.073
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