GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. To associ...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Okonechnikov, Konstantin, Hübner, Jens-Martin, Kraft, Katerina, Hidalgo, Rocio Acuna, Bump, Rosalind, Chandran, Sahaana, Mundlos, Stefan, Mesirov, Jill, Pajtler, Kristian, Dixon, Jesse, Pfister, Stefan, Kool, Marcel, Chavez, Lukas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Genetics/Epigentics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477292/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.073
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