ATIM-27. TUMOR MUTATIONAL BURDEN PREDICTS RESPONSE TO ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF TRANSCRIPTIONAL AND IMMUNOLOGICAL CORRELATES

BACKGROUND: The live attenuated oral poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal cell adhesion molecule and tumor antigen widely expressed ectopically in malign...

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Vydáno v:Neuro Oncol
Hlavní autoři: Gromeier, Matthias, Brown, Michael, Beuabier, Nike, Yan, Hai, He, Yiping, Zhang, Gao, Desjardins, Annick, Herndon, James, Bolognesi, Dani, Friedman, Allan, Friedman, Henry, McSherry, Frances, Lin, Xiang, Wei, Zhi, Nair, Smita, Peters, Katherine, Randazzo, Dina, Sampson, John, McLendon, Roger, Bigner, Darell, Ashley, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Adult Clinical Trials–Immunologic
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847607/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.026
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