ATIM-27. INTRATUMORAL ADMINISTRATION OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF MUTATIONAL RESPONSE CORRELATES

BACKGROUND: The live attenuated oral poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal cell adhesion molecule and tumor antigen widely expressed ectopically in malign...

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Опубликовано в: :Neuro Oncol
Главные авторы: Ashley, David, Desjardins, Annick, Gromeier, Matthias, Muscat, Andrea, Herndon, James, Friedman, Allan, Friedman, Henry, McSherry, Frances, Randazzo, Dina, Peters, Katherine, Threatt, Stevie, Bullock, Chevelle, Miller, Elizabeth, Boulton, Susan, Lipp, Eric, Bigner, Darell, Sampson, John
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216141/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.022
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