ATIM-36. DOSE ESCALATION TRIAL OF D2C7 IMMUNOTOXIN (D2C7-IT) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (MG)

BACKGROUND: D2C7-IT is a recombinant immunotoxin comprised of a dual-specific antibody fragment targeting EGFRwt and EGFRvIII and a genetically engineered form of the Pseudomonas exotoxin, PE38-KDEL. We report results of a phase 1 trial evaluating D2C7-IT delivered intratumorally by CED. METHODS: El...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Peters, Katherine, Johnson, Margaret, Thomas, Leslie, Threatt, Stevie, Bullock, Chevelle, Herndon, James, Boulton, Susan, Healy, Patrick, Lipp, Eric, Sampson, John, Friedman, Allan, Friedman, Henry, Ashley, David, Bigner, Darell
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216151/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.031
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