IMMU-21. TARGETING EGFR IN HYPOMUTATED PEDIATRIC BRAIN TUMORS USING THE D2C7 IMMUNOTOXIN

BACKGROUND: EGFR is a receptor tyrosine kinase that is hyperactivated or overexpressed in many human cancers. Compared with brain tumors in adults, pediatric tumors harbor few somatic mutations, which reduces the antigenic burden and number of potential molecular targets. Compared to checkpoint agen...

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Vydáno v:Neuro Oncol
Hlavní autoři: Landi, Daniel, Thompson, Eric, McLendon, Roger, Desjardins, Annick, Chandramohan, Vidya, Ashley, David, Bigner, Darell
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012903/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.337
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