IMMU-21. TARGETING EGFR IN HYPOMUTATED PEDIATRIC BRAIN TUMORS USING THE D2C7 IMMUNOTOXIN

BACKGROUND: EGFR is a receptor tyrosine kinase that is hyperactivated or overexpressed in many human cancers. Compared with brain tumors in adults, pediatric tumors harbor few somatic mutations, which reduces the antigenic burden and number of potential molecular targets. Compared to checkpoint agen...

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Опубликовано в: :Neuro Oncol
Главные авторы: Landi, Daniel, Thompson, Eric, McLendon, Roger, Desjardins, Annick, Chandramohan, Vidya, Ashley, David, Bigner, Darell
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012903/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.337
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