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Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry
[Image: see text] The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2-type tumor growth and metastasis in mice by ∼90%. This study reports the pharmacokinetics and tiss...
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| Wydane w: | ACS Omega |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2019
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6843717/ https://ncbi.nlm.nih.gov/pubmed/31720502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01641 |
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