Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry

[Image: see text] The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2-type tumor growth and metastasis in mice by ∼90%. This study reports the pharmacokinetics and tiss...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Maldonado, María del Mar, Rosado-González, Gabriela, Bloom, Joseph, Duconge, Jorge, Ruiz-Calderón, Jean F., Hernández-O’Farrill, Eliud, Vlaar, Cornelis, Rodríguez-Orengo, José F., Dharmawardhane, Suranganie
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843717/
https://ncbi.nlm.nih.gov/pubmed/31720502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01641
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