Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell cycle progression. Accordingly, our recently developed Rac inhibitor EHop-016 (IC(50),...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Hernandez-O’Farrill, Eliud, Borrero-Garcia, Luis D., Forestier-Roman, Ingrid, Gerena, Yamil, Blanco, Manuel, Rivera-Robles, Michael J, Rodriguez-Medina, José R, Cubano, Luis A, Vlaar, Cornelis P, Dharmawardhane, Suranganie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418092/
https://ncbi.nlm.nih.gov/pubmed/28450422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0442
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