Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell cycle progression. Accordingly, our recently developed Rac inhibitor EHop-016 (IC(50),...

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Publicat a:Mol Cancer Ther
Autors principals: Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Hernandez-O’Farrill, Eliud, Borrero-Garcia, Luis D., Forestier-Roman, Ingrid, Gerena, Yamil, Blanco, Manuel, Rivera-Robles, Michael J, Rodriguez-Medina, José R, Cubano, Luis A, Vlaar, Cornelis P, Dharmawardhane, Suranganie
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418092/
https://ncbi.nlm.nih.gov/pubmed/28450422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0442
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