Pharmacokinetics of Rac Inhibitor EHop-016 in Mice by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

The Rho GTPase Rac is an important regulator of cancer cell migration and invasion; processes required for metastatic progression. We previously characterized the small molecule EHop-016 as a novel Rac inhibitor in metastatic breast cancer cells and recently found that EHop-016 was effective at redu...

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發表在:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Corujo-Carro, Francheska, Duconge, Jorge, Hernandez-O’Farrill, Eliud, Vlaar, Cornelis, Rodriguez-Orengo, Jose F., Cubano, Luis, Dharmawardhane, Suranganie
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306626/
https://ncbi.nlm.nih.gov/pubmed/25594952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2014.12.021
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