Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell cycle progression. Accordingly, our recently developed Rac inhibitor EHop-016 (IC(50),...

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發表在:Mol Cancer Ther
Main Authors: Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Hernandez-O’Farrill, Eliud, Borrero-Garcia, Luis D., Forestier-Roman, Ingrid, Gerena, Yamil, Blanco, Manuel, Rivera-Robles, Michael J, Rodriguez-Medina, José R, Cubano, Luis A, Vlaar, Cornelis P, Dharmawardhane, Suranganie
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418092/
https://ncbi.nlm.nih.gov/pubmed/28450422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0442
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