Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae

The Rho GTPase Cdc42 is highly conserved in structure and function. Mechanical or chemical cues in the microenvironment stimulate the localized activation of Cdc42 to rearrange the actin cytoskeleton and establish cell polarity. A role for Cdc42 in cell polarization was first discovered in the buddi...

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Dades bibliogràfiques
Publicat a:Small GTPases
Autors principals: Rivera-Robles, Michael John, Medina-Velázquez, Julia, Asencio-Torres, Gabriela M., González-Crespo, Sahily, Rymond, Brian C., Rodríguez-Medina, José, Dharmawardhane, Suranganie
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549613/
https://ncbi.nlm.nih.gov/pubmed/29969362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2018.1495008
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