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Targeting Rac and Cdc42 GEFs in Metastatic Cancer

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion. This review will focus on the close homologs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Dev Biol
Prif Awduron: Maldonado, Maria del Mar, Medina, Julia Isabel, Velazquez, Luis, Dharmawardhane, Suranganie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156542/
https://ncbi.nlm.nih.gov/pubmed/32322580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00201
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