DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation

A minority of cancers have breast cancer gene (BRCA) mutations that confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis), but the role for PARPis in BRCA-proficient cancers is not well established. This suggests the need for novel combination therapies to expand the use of t...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Abbotts, Rachel, Topper, Michael J., Biondi, Christopher, Fontaine, Daniel, Goswami, Reena, Stojanovic, Lora, Choi, Eun Yong, McLaughlin, Lena, Kogan, Aksinija A., Xia, Limin, Lapidus, Rena, Mahmood, Javed, Baylin, Stephen B., Rassool, Feyruz V.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842607/
https://ncbi.nlm.nih.gov/pubmed/31591209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903765116
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